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COURSE : ADVANCED TOPICS IN BIOLOGICAL AND MEDICAL ENGINEERING
TRANSLATION : TOPICOS AVANZADOS EN INGENIERIA BIOLOGICA Y MEDICA
COURSE CODE : IBM3101
CREDITS : 10 UC / 6 SCT
MODULES : 03
PREREQUISITE COURSES: --
CONNECTOR :
RESTRICTIONS : Curriculum 040201 o 040301 o 040401 o 140601 o 148101 o 120401 o 120501 o 120801 0 180001 0 181001
CHARACTER : Minimum
TYPE : Lecture
QUALIFICATION: Standard
DISCIPLINE : Engineering, Biology and Medicine


I. DESCRIPTION

This course provides a general view of regenerative medicine and tissue engineering including topics such as biocompatibility, vascularization, degradable scaffolds, cell therapies, cellularized scaffolds, and the use
of biological and chemical factors to improve tissue repair and regeneration. Moreover, it will cover a wide selection of mathematical models in physiology and biomechanics, showing how physiological problems can be
formulated and studied mathematically, and how such models give rise to interesting and challenging mathematical questions. At the same time, the course shows how biomechanical principals are applied to the
modeling of biological tissue.

II. OBJECTIVES

1. Explain and apply basic concepts of tissue regeneration, biomechanics and mathematical modeling of physiological systems
2. Compare different alternatives to improve tissue regeneration using artificial scaffolds, and factors
3. Develop and build engineering models dat describe physiological systems such as the cardiovascular and the respiratory system
4. Analyze scientific literature on tissue engineering, regenerative medicine, biomechanics and quantitative physiology
5. Communicate scientific information both by written documents and oral presentations, to specific audiences


III. CONTENT

1. Introduction to tissue engineering and regeneration
1.1. History of tissue engineering
1.2. Biomimetic approaches
1.3. Cell, tissue, and organ development
1.4. Cell-ECM interactions
2. In vitro control of tissue regeneration
2.1. Tissue development in vitro
2.2. Use of degradable scaffolds
2.3. Cell-material interactions
2.4. Biocompatibility and cytotoxicity
2.5. Immunomodulation
2.6. Vascularization
2.7. Stem cells
3. In vivo tissue engineering
3.1. Case studies: tissue engineering of skin, muscle, bone, etc.
3.2. Animal and clinical studies
3.3. Regulatory considerations
4. Introduction to biomechanics and quantitative physiology
4.1. controlling mechanisms in human body
4.2. balance laws and biophysical principals
5. Mathematical models of physiological systems:
5.1. Electrical conduction system of the heart
5.2. Hemodynamics and the cardiovascular system
5.3. Respiratory system
5.4. Muscle - skeletal system
5.5. Nervous system


IV. METHODOLOGY
? Lectures and Case Studies
? Assignments
? Development and presentations of application project (s)


V. EVALUATION
? Quizzes (40 %)
? Assignments and reports (30%)
? Final written report (15%)
? Oral defense of the applied project (15%)


VI. BIBLIOGRAPHY
Minima:
? Humphrey, J. D., O?Rourke, S. L. (2015) An Introduction to Biomechanics. Solids and Fluids, Analysis and Design, 2nd edition, Springer: New York.
? Keener, J. & Sneyd, J. (2009) Mathematical Physiology, Springer: New York.
? Lanza, R., Langer, R. & Vacanti, R. (2007) Principals of Tissue Engineering. 3rd edition. Elsevier: Amsterdam.
? Ratner, B.D., Hoffman, A.S., Schoen, F.J., Lemons, J.E. (2004) Biomaterials Science: an introduction to materials in medicine. 2nd edition. Elsevier: London.

Complementary:
The literature will be defined in accordance with the topics studied.