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CURSO:PROTOTYPING FOR BIOENGINEERS
TRADUCCION:DISE?O DE PROTOTIPOS EN BIOINGENERIA
SIGLA:IBM2026
CREDITOS:10
MODULOS:03
CARACTER:OPTATIVO
TIPO:CATEDRA Y LABORATORIO
CALIFICACION:ESTANDAR
PALABRAS CLAVE:IMPRESION 3D; DISE?O CAD; LIBRE HARDWARE; DISE?O GENETICO; MICROFLUIDOS
NIVEL FORMATIVO:PREGRADO


I.DESCRIPCIÓN DEL CURSO

This course allows students to develop practical skills to design and build prototypes in engineering (hardware) and biology (DNA, microbial ecosystems and in vitro reactions). It covers the theoretical (lectures) and practical (laboratory) basics of modern digital fabrication, integration and automation, and prototyping with biology. For practical learning, every student will start a biological culture, design a 3D printed object, assemble a microscope prototype and use it in a problem-solving challenge to monitor fermentation in a microfluidic chip. Through lectures and research, students will also learn where to find resources for prototyping, how to manage files, document openly and collaborate with other makers online.
Evaluation will be based on participation, presentations, prototyping and written products.


II.RESULTADOS DE APRENDIZAJE

1.Manage digital design files online for version control and collaboration.

2.Design a digital object for 3D printing scientific devices or parts under consideration of practical fabrication constraints.

3.Use electronic tools and software for the automation of research instruments.

4.Design open biological systems with a given desirable function utillising cell-free technology.

5.Control open biological processes with open hardware, using both skills from engineering and biology.

6.Discuss the main approaches of rapid prototyping for biological engineering projects.


III.CONTENIDOS

1.Modern prototyping is open, digital rapid prototyping
1.1.Working on GitHub
1.2.Documentation
1.3.Collaborating online

2.Digital fabrication
2.1.3D printing, bioprinting and CNC
2.2.CAD design
2.3.Molding and casting

3.Integration and automation
3.1.Electronic tools for open prototyping
3.2.Instrumentation integration and automation (microscope)
3.3.Introduction to microfluidics and organs on a chip

4.Prototyping with biology
4.1.Genetic prototyping and cell-free biology
4.2.Fermentation and biomaterials
4.3.Resource development


IV.ESTRATEGIAS METODOLOGICAS

-Problem solving.

-Case studies.

-Lectures.

-Laboratory and practical learning.

-Research and presentation.


V.ESTRATEGIAS EVALUATIVAS

-Participation in classes: 25%

-Prototyping products: 25%

-Written products: 25%

-Presentation: 25%


VI.BIBLIOGRAFIA

Minimum

J. Swartz. Cell-Free Protein Expression. ISBN 978-3-642-63939-5

Open-Source Lab. https://doi.org/10.1016/C2012-0-07249-3

M. Pavlovic "Bioengineering, a conceptual approach" ISBN 978-3-319-10797-4

Alicia Gibb "Building Open Source Hardware: DIY Manufacturing for Hackers and Makers". ISBN-10: 0321906047


Complementary

Joan Horvath "Mastering 3D Printing" ISBN-13 (pbk): 978-1-4842-0026-1

Kimmo Karvinen and Tero Karvinen "Getting Started with Sensors - Measure the World with Electronics, Arduino, and Raspberry Pi" ISBN: 978-1-449-36708-4

Massimo Banzi and Michael Shiloh "Getting Started with Arduino" ISBN: 978-1-4493-6333-8

Tian WC., Finehout E. "Microfluidics for Biological Applications" ISBN: 978-0-387-09479-3

Jin-Ming Lin "Microfluidics for Single-Cell Analysis" ISBN 978-981-32-9728-9

U. Meyer, T. Meyer, J. Handschel, H.P. Wiesmann "Fundamentals of Tissue Engineering and Regenerative Medicine" ISBN: 978-3-540-77754-0

T.A. Brown "Gene Cloning and DNA Analysis" ISBN 978-1-4051-8173-0

J. Lodge, P. Lund, S. Minchin "Gene Cloning, Principles and Applications" ISBN 0-203-96728-3


PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
INSTITUTO DE INGENIERIA BIOLOGICA Y MEDICA / NOVIEMBRE 2020